Sorting machineries: how platelet-dense granules differ from α-granules
نویسندگان
چکیده
منابع مشابه
P29: The Role of Platelet Granules in Neuroinflammation
Platelets are known to contribute to vascular pathologies, however, their role in inflammatory disorders of the central nervous system (CNS), such as multiple sclerosis (MS) and its mouse model, experimental autoimmune encephalomyelitis (EAE), is thus far poorly defined. Although there is emerging evidence that platelets might accumulate in the CNS parenchyma along with an increased activation ...
متن کاملGranule exocytosis is required for platelet spreading: differential sorting of α-granules expressing VAMP-7.
There has been recent controversy as to whether platelet α-granules represent a single granule population or are composed of different subpopulations that serve discrete functions. To address this question, we evaluated the localization of vesicle-associated membrane proteins (VAMPs) in spread platelets to determine whether platelets actively sort a specific subpopulation of α-granules to the p...
متن کاملCalcium-containing Platelet Granules
Calcium has long been recognized as an essential factor for platelet adhesion and subsequent blood coagulation, and anticoagulation can be achieved with the use of calcium chelators such as EDTA or citrate . The normal level of calcium in plasma is approximately 0 .1 mg/ml; however, dry weight chemical analysis of platelets (5) has indicated that they contain as much as 3 .0 or 4.5 mg calcium/g...
متن کاملGray platelet syndrome: macrothrombocytopenia with deficient α-granules.
A 7-year-old boy of Pakistani origin was referred for thrombocytopenia and possible IgA deficiency. His medical history was significant for frequent upper respiratory tract infections and otitis media. There was no history of epistaxis, oropharyngeal bleeding, petechiae, bruising, or other bleeding problems. Physical examination was normal with no evidence of hepatosplenomegaly. Laboratory eval...
متن کاملPlatelet granules in vascular integrity.
In this issue of Blood, Deppermann et al dissect the role of platelet granule secretion in maintaining vascular integrity during inflammation. The authors show that mice lacking platelet granule secretion do not bleed in skin or lung inflammation models. Lack of platelet release however resulted in increased brain hemorrhage after experimental stroke. The latter finding is of clinical importanc...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bioscience Reports
سال: 2018
ISSN: 0144-8463,1573-4935
DOI: 10.1042/bsr20180458